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By Dr. Sakshi Sahil Bansal in Obstetrics And Gynaecology
Jan 07 , 2026 | 4 min read
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The Quadruple Marker Test (QMT) is a prenatal blood test that helps assess the health of an unborn baby. It screens for genetic conditions, chromosomal abnormalities, and neural tube defects. The test is highly recommended for pregnant women, especially those at higher risk of complications.
If you are an expecting mother, getting the Quadruple Marker Test can provide important insights into your baby’s health, allowing for early medical intervention if needed.
What is the Quadruple Marker Test?
The Quadruple Marker Test, also known as the Quad Test, is a blood screening test performed during the second trimester of pregnancy. It measures four key substances in the mother’s blood:
- Alpha-fetoprotein (AFP): A protein produced by the fetus that helps detect neural tube defects.
- Human Chorionic Gonadotropin (hCG): A hormone produced by the placenta; abnormal levels may indicate chromosomal abnormalities like Down syndrome.
- Estriol: An estrogen hormone produced by the baby and placenta; low levels can be linked to certain birth defects.
- Inhibin A: A protein hormone; high levels may indicate a higher risk of chromosomal disorders.
What Does the Quadruple Marker Test Check For?
This test helps detect:
- Down Syndrome (Trisomy 21) – A genetic disorder that affects a baby’s development.
- Trisomy 13 & 18 – A severe chromosomal disorder leading to developmental delays.
- Neural Tube Defects – Conditions like spina bifida, where the spinal cord does not develop properly.
- Fetal Development Issues – Abnormal hormone levels can indicate complications during pregnancy.
Quadruple Marker Test Normal Range
The normal range for the test varies depending on the mother’s age, weight, and gestational age. However, typical values are:
|
Marker |
Normal Range |
|
Alpha-fetoprotein (AFP) |
10 – 150 ng/mL |
|
Human Chorionic Gonadotropin (hCG) |
1,000 – 50,000 mIU/mL |
|
Estriol |
0.5 – 3.0 ng/mL |
|
Inhibin A |
Less than 2.0 MoM |
If the values are outside the normal range, further testing like an amniocentesis may be recommended.
Read More: Pregnancy Due Date Calculator
Quadruple Marker Test Price
At Max Hospital, we offer comprehensive and affordable prenatal screening with accurate results. Our state-of-the-art facilities ensure reliable testing, helping expectant mothers make informed decisions about their pregnancy.
Who Should Get the Quadruple Marker Test?
This test is particularly recommended for:
- Pregnant women over the age of 35.
- Women with a family history of genetic disorders.
- Expectant mothers with abnormal ultrasound findings.
- Those who have had previous pregnancies with birth defects.
- Women exposed to harmful substances during pregnancy.
Quadruple Marker Test Results
- Low AFP + High hCG + Low Estriol + High Inhibin A → Increased risk of Down syndrome.
- Low levels of all markers → Possible risk of Trisomy 18 & Trisomy 13.
- High AFP levels → Possible neural tube defects like spina bifida.
Doctors analyze these results along with other factors like ultrasound findings and medical history before making a diagnosis.
Composition and Role of Each Marker in the Test
- Alpha-fetoprotein (AFP): Produced by the fetal liver, AFP helps detect neural tube defects.
- Human Chorionic Gonadotropin (hCG): A hormone that indicates the risk of Down syndrome and other abnormalities.
- Estriol: A form of estrogen that plays a crucial role in fetal development.
- Inhibin A: A protein that can indicate chromosomal abnormalities when levels are abnormal.
Uses of the Quadruple Marker Test
- Prenatal Screening: Detects genetic disorders early in pregnancy.
- Risk Assessment: Helps identify potential birth defects.
- Pregnancy Health Monitoring: Assesses the overall well-being of the fetus.
- Guidance for Further Testing: Helps doctors determine if additional diagnostic tests are needed.
Side Effects & Risks of the Test
The Quadruple Marker Test is a simple blood test with minimal risks, but some individuals may experience:
- Mild Bruising – Slight discomfort at the blood draw site.
- Dizziness or Lightheadedness – Rare cases of feeling faint after the test.
- Anxiety About Results – Some patients may feel stressed while waiting for results.
Why Choose Max Hospital for the Quadruple Marker Test?
At Max Hospital, we offer:
- Advanced Diagnostic Technology – Ensuring precise and accurate results.
- Expert Medical Team – Experienced professionals guiding you throughout.
- Comprehensive Prenatal Care – Supporting you at every stage of pregnancy.
Book Your Quadruple Marker Test Today!
Early detection is key to ensuring a healthy pregnancy. Schedule your Quadruple Marker Test at Max Hospital today and get the best prenatal care for you and your baby!
Call us at [hospital contact] or Book an Appointment Online.
FAQs
Can the Quadruple Marker Test be done at home?
No, the test requires a blood sample drawn at a diagnostic centre or hospital.
Is the Quadruple Marker Test done before surgery?
No, this test is specific to pregnancy and is not used before surgeries.
When is the Quadruple Marker Test performed?
It is usually done between 15 to 20 weeks of pregnancy for the most accurate results.
What happens if my Quadruple Marker Test results are abnormal?
If your results are abnormal, your doctor may recommend additional tests like amniocentesis or ultrasound to confirm the findings.
Is fasting required before the Quadruple Marker Test?
No fasting is required. You can take the test at any time of the day.
How long does it take to get Quadruple Marker Test results?
Results are usually available within 3 to 5 days.
How accurate is the Quadruple Marker Test?
While the test provides valuable insights, it is a screening tool, not a diagnostic test. Further evaluation may be required.
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